Skeletal muscle is one of the major organs involved in metabolism. Aging and chronic metabolic diseases, like type 2 diabetes, are generally associated with a significant loss of skeletal muscle mass. Muscle wasting eventually leads to muscle weakness and major disabilities in day-to-day life. Therefore, various interventions have been proposed to reduce or reverse the loss of muscle mass and function.
Most attention so far was paid to endurance type of exercise. In this thesis we focus on the beneficial effects of resistance exercise and the proposed importance of the ingestion of carbohydrate, protein and/or specific amino acids as a means to augment muscle protein anabolism.
Defence date: 22/06/06