This thesis focuses on the modulation of fat oxidation by nutritional and pharmacological interventions in overweight/obese subjects. It is described what the role is of slowly digestible carbohydrates, trehalose and isomaltulose, on insulinemic and glycemic responses, postprandial lipolysis and fat oxidation in healthy overweight subjects and subjects with impaired glucose tolerance. In addition, the effects of a 3 day supplementation of EGCG on fat oxidation in overweight subjects is described.

As nutritional modifications have not always been successful, the effects of a pharmacological agent, liraglutide, in obese subjects on substrate oxidation, glucose metabolism, gastric emptying and food intake was investigated.

Defence date: 31/10/12

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van Can, J.G.P.
van Can, J.G.P.
Clinical Research Associate