Various situations, such as the recovery from illness or rehabilitation after injury, may necessitate a period of physical inactivity in otherwise healthy individuals. This muscle disuse during a period of leg immobilization or bed rest leads to the loss of muscle mass and strength and can have numerous resultant negative health consequences.
We need insight in the mechanism(s) responsible for disuse-related muscle atrophy to develop effective interventional strategies to preserve muscle mass and offset the negative health consequences of muscle disuse. In this thesis we examine the various aspects of skeletal muscle disuse atrophy and investigate the efficacy of various interventional strategies to combat disuse atrophy.
Defence date: 11/18/16