Abstract
Androgen deprivation therapy (ADT) is the mainstay in the treatment of (locally) advanced prostate cancer. By suppressing testosterone, ADT inhibits prostate tumor growth. However, the decline in testosterone levels also results in numerous adverse effects, including an increase in body fat mass and a decrease in skeletal muscle mass. In the first part of this thesis, the adverse effects of ADT are further explored. Thereafter, the efficacy of resistance exercise training to counteract the adverse effects on body composition, skeletal muscle mass, muscle strength, and aerobic capacity are assessed. In addition, it is examined whether protein supplementation can further augment the exercise-induced benefits. As ADT is generally prescribed for two or more years, the sustainability of these exercise-obtained on the long term are subsequently examined. In the second last part of the thesis, the focus is shifted to exercise as a potential strategy to attenuate tumor progression. By motivating patients to adopt a sedentary or active lifestyle in the week prior to prostatectomy, the potential impact of physical activity on prostate tumor protein synthesis rates is assessed. The thesis concludes with implications for clinical practice. The proven efficacy of resistance exercise training during ADT, advocates its implementation in the standard care for prostate cancer patients and advises, challenges, and suggestions for further research are provided.
Defence date: 11/01/2024
Sint Maartenskliniek
